Some of the animals received lower doses, while others were given more. The dosage is said to have been "the allometrically scaled mouse equivalent doses of the maximum recommended human maintenance dose of CBD in EPIDIOLEX (20 mg/kg)." The research on mice we have referred to in this article shows that CBD is likely to affect the liver. We also know that CBD reduces the liver’s efficiency in metabolizing medicine by inhibiting the CYP450 enzymes.

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That’s why choosing CBD products made with indoor-grown hemp is the safest option. But wait, didn’t we just learn that CBD inhibits the activity of enzymes in your liver?

• In some studies, CBD oil caused side effects including fatigue and changes in appetite.
• CBD oil is well-tolerated considered safe for use but may interact with existing medications.
• Also known as cannabidiol, CBD is extracted from the buds, stalks and flowers of the cannabis sativa plant.

With this information, it would be wise for people with liver problems to avoid using CBD or only use it in consultation with their doctors. Manufacturers also subject their products to third-party testing by approved laboratories.

The latest study also finds that CBD has the potential for herbal and drug interactions. "CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes,"the study reads. Researchers then spent some time examining mice under the influence of various doses of CBD.

Just because CBD was from the same plant as THC, the argument went, this cannabinoid was marijuana even though it doesn’t have intoxicating effects. Because of the legally murky nature of marijuana, the FDA has not stepped in to regulate products like CBD oil, Bonn-Miller said. States are struggling to put regulations in place, but they don’t have the deep pockets of the federal government. There also are concerns about both the quality of CBD oil being produced and its potential side effects, the experts added. HealthDay ReporterMONDAY, May 7, Cannabidiol oil has become the hot new product in states that have legalized medical marijuana.

As a foreign correspondent, I covered cannabis during the blood diamond wars in Sierra Leone. In 2018 I received an AxisWire Star Media Award for Best Freelance Cannabis Writer. My coverage has a penchant for social justice issues and equality.

Yes, that’s true, but heightened levels of enzymes can be an indicator of liver damage. Now that you have a basic idea of how CBD interacts with your liver, it’s easier to understand why there might be concern regarding CBD and liver toxicity. Like any new substance that’s gaining popularity on the consumer market, it’s essential that we do our due diligence as a society and investigate CBD to the fullest. Thanks to the factors we listed earlier, however, the capacity for such research is unreasonably diminished, causing CBD treatment consumers to jump on any evidence on CBD’s potential health risks and benefits that they might come across. Even though we’ve known that CBD is non-intoxicating for decades, the misguided global efforts associated with the “war on drugs” brought into being a new age of superstition and remarkably unscientific thinking.

In 2020, I was listed on Green Market Report’s 100 Most Important Women In Weed. As a public speaker, I have appeared at the Cannabis Media Summit, CannaTech, Collision, Pot or Not, World Cannabis Congress, the Green Market Summit, CWCBE, NCIA, iC3, cLAB, entOURage, and Cannabis Europa.

I am a United Nations-based cannabis correspondent and global drug policy analyst. My work has been syndicated worldwide in various media outlets from The New York Times to High Times.